Proton Pump Inhibitors Vs H2 Blockers

Proton Pump Inhibitors Vs H2 Blockers. Society and cultureAvailabilityMedical usesTreatmentAdministrationH2 blockers reduce acid production whereas PPIs block acid production altogether So PPIs are considered much stronger Many H2 blockers are available and most are over the counter (OTC) and do not require a doctors prescription They come in generic or plain forms that are cheaper than the proprietary or marketed forms of the same drug For the most part both forms of the drugs work about the same and for mild to moderate acid reflux the generics are a cost savings and work fine There are four H2 blockers available in the United States and are sold under several names Some OTC H2 blockers are marketed at half of the usual prescription strength it is important to read the label to see the strength and dose The prices in the table are approximate and are included only to show you that the generics are dramatically cheaper than the proprietary drugs The dosing given is average or usual dosing the actual dosing for acid reflux could be less or more depending on the severity of your acid reflux so read the dosing recommendations on the package label As mentioned these are all available without a prescription but many nonprescription drugs are not covered under most prescription drug insurance plans Higher dosing may be available with a doctors prescription and could be medications covered by insurance In most states there is usually a mandatory substitution to a generic drug if you use a doctors prescription Currently only one overthecounter PPI Prilosec OTC is available all others require a prescription Omeprazole is available only by prescription Despite the previous comment that proprietary and generic drugs are about the same in my experience Prilosec OTC is a much more effective drug and costs a quarter as much as the generic H2 blockers are effective for mild to moderate acid reflux symptoms These drugs have been shown in medical studies to be effective in healing esophagitis (inflammation of the lining of the esophagus) And once healed H2 blockers are effective in maintaining healing of esophagitis when used longterm Proton pump inhibitors as a group are overall much more effective for controlling stomach acid production than H2 blockers are Proton pump inhibitors are the drug of choice for severe acid reflux symptoms esophagi tis strictures and Barretts esophagus Sometimes PPIs are used to heal esophageal damage and then patients are switched to an H2 blocker for longterm maintenance In many studies proton pump inhibitors have been shown to be more effective than H2 blockers are in healing esophagitis and maintaining healing And if symptoms cannot be controlled with an H2 blocker then longterm PPIs are continued H2 blockers come as pills and a few as elixirs or liquids After you take the pills an H2 blocker takes about an hour to start working So an antacid might be a better choice if your reflux has already started Some OTC H2 blockers such as famotidine/calcium carbonate/magnesium hydroxide (Pepcid Complete) come with an antacid included are effective immediately and can last up to 12 hours For those with predictable occasional acid reflux the medication should be taken before symptoms occur For example if you are going out for spicy food and are going to have a few alcoholic drinks take an H2 blocker prior to the meal If you only have nighttime acid reflux then take medication before bed If you have acid reflux daily and several times a day then take a full dose daily to be more effective Most H2 blockers reduce acid production for 6 to 12 hours and accordingly depending on the particular drug you can take them anywhere from two to four times a day Despite the fact that PPIs are strong they are virtually useless if heartburn is already present because PPIs can take hours to a day to start working These drugs are most effectively used to prevent acid reflux from occurring So PPIs should be taken regularly once or twice a day not just on the spot when heartburn occurs A common misconception among patients who take PPIs is that they feel the drug does not work when really they are taking it incorrectly Further PPIs are very sensitive and do not work effectively if you do not take them at the appropriate time All PPIs must be taken 30 to 45 minutes before eating food This recommendation cannot be stressed enough Many patients take PPIs when they get up in the morning and then they do not eat breakfast or they take the medication at bedtime for nighttime acid refluxthis is incorrect If the drug is taken once a day it should be a half hour before breakfast If a PPI is taken twice a day the additional dose is taken half an hour before dinner Taking a PPI appropriately will ensure you get the maximum benefit from the medication.

Use of PPI in a CKD population was not associated with increased mortality or progression to ESKD when compared to H2 blocker and to no acid suppressing therapy Protonpump inhibitor vs H2receptor blocker use and overall risk of CKD progression Author Liza Cholin Tarek Ashour Ali Mehdi Jonathan J Taliercio Remy Daou Susana Arrigain Jesse D ScPublish Year 2021.

H2 Blockers vs. PPIs: Which Is Safer? Drugwatcher.org

When compared with the use of H2RAs the pooled RR of CKD in patients with PPI use was 129 (95% CI 122136) Conclusions Our study demonstrates statistically significant 13fold increased risks of CKD and ESRD in patients using PPIs but not in patients using H2RAs Author Karn Wijarnpreecha Charat Thongprayoon Supavit Chesdachai Panadeekarn Panjawatanana Patompong UnCited by Publish Year 2017.

The Difference Between Proton Pump Inhibitors (PPI), H2

H2 receptor blockers and proton pump inhibitors are both used to reduce stomach acid and relieve the symptoms of acid reflux or GERD Although side effects are less common with PPIs they tend to be more serious when they occur For instance Nexium a PPI medication was the topic of recently filed complaints in the court Author Erica Davies.